🚀 Senior LCMS Scientist

Senior Scientist – Subject Matter Expert (SME) in Mass Spectrometry

Up to £45,000 + Benefits

Full-time, On-site – Southampton

We’re partnering with an innovative scientific organisation to find an experienced Senior Scientist with deep expertise in Mass Spectrometry to join a high-performing team based in Southampton. This role offers the chance to lead analytical strategies, contribute to cutting-edge projects, and support the development of high-quality modified nucleic acid in a fast-paced, collaborative environment.

About the Role

As the subject matter expert in mass spectrometry, you’ll play a central role in driving analytical method development, ensuring high standards in nucleic acid production, and mentoring junior team members. This is a hands-on role in a modern laboratory, where scientific excellence and operational efficiency go hand-in-hand.

Key Responsibilities

• Lead and manage analytical workflows using LC-MS, UPLC-MS, HPLC, PAGE, and flash chromatography
• Act as the go-to expert for mass spectrometry, including troubleshooting and continuous improvement
• Collaborate with cross-functional teams to support small molecule preparation and oligonucleotide synthesis
• Maintain, calibrate, and optimise analytical instrumentation in line with internal and ISO quality standards
• Support and mentor Associate Scientists and Lab Technicians, providing technical guidance and training
• Ensure high levels of documentation accuracy and data integrity
• Uphold Health, Safety and Environmental (HSE) standards and promote a safety-first culture
• Manage the inventory of analytical reagents and consumables
• Stay informed on emerging techniques in nucleic acid chemistry and analytical science

About You

We’re looking for a driven and detail-focused scientist who thrives in a collaborative lab environment and is passionate about pushing the boundaries of analytical science.

You’ll ideally have:

• PhD in Chemistry, Analytical Chemistry, or a closely related field
• Significant hands-on experience with Mass Spectrometry, ideally including Waters LC-MS systems (Waters Connect experience highly desirable)
• Proven track record in high-throughput chemistry or oligonucleotide production environments
• Strong grounding in nucleic acid chemistry and experience with purification techniques
• Experience working in ISO or GMP-regulated environments
• Ability to lead projects and mentor junior staff
• Excellent communication, problem-solving and organisational skills
• A proactive mindset, able to adapt and perform under pressure

Salary & Benefits

• Salary: Up to £45,000 depending on experience
• Location: On-site in Southampton
• Holidays: 25 days annual leave + 8 bank holidays
• Pension: 6% employer contribution
• Work-Life Balance: Flexible working hours
• Life Assurance: 4x salary
• Other Benefits:
• Long service awards
• Reward and recognition scheme
• Employee Assistance Programme with 24/7 remote GP access
• Annual flu vaccinations
• Cycle to work scheme
• Gym discounts
• Discount and savings platform
• Professional membership reimbursement
• Referral incentives
• Social events and volunteering days

Want to lead innovation in mass spectrometry and oligonucleotide production?

If you're ready to make an impact in a dynamic and supportive environment, we’d love to hear from you. Apply today or get in touch to learn more.